Nature‐Inspired Multifunctional Nano‐Microreactors: Pd Nanoclusters‐Integrated Bioengineered Skin Channels for Effectively Overcoming Product Inhibition and Hydrogen Adherence Challenges During Hydrogen Production

Abstract Nature‐inspired design principles offer powerful strategies for engineering advanced catalytic materials with multifunctional microenvironment proximal to active sites. Here, bioengineered multifunctional skin nano–microchannels (N─MCs) integrated with Pd nanoclusters (Pd/N─MCs) are presented for the first time for remarkably preventing challenges of product inhibition and hydrogen adherence during its generation from ammonia borane (AB). Pd/N─MCs, with its peculiar mechanism of action, differentiate it from all the reported catalytic systems till date, which are known to be affected/deactivated by product inhibition and hydrogen adherence. The N─MCs feature a unique hydrophilic–aerophobic environment and tunable surface chemistry, effectively mitigating product inhibition and hydrogen bubble adherence during its performance. The lysyl‐rich matrix of hierarchically‐assembled collagen facilitates AB uptake and activation at Pd sites, while promoting borate desorption to sustain high catalytic turnover. The aqueous microchannels, with a hydrogen bubble contact angle of ≈153°, destabilize generated hydrogen gas bubbles and facilitate their release. Additionally, exhaustive methylation of lysyl amino groups results in positively charged [Pd/N─MCs]⁺, enhancing microenvironment polarity and achieving a high turnover frequency (TOF) of 3589 h ⁻¹ . This nature‐inspired platform bridges biological precision with materials science, providing a scalable and sustainable strategy for multifunctional nano–microreactors and advancing nature‐inspired systems for efficient hydrogen production.