journal article·2025-06

Bioinspired Membrane‐Based Cancer Vaccines for Immunotherapy: Progress and Perspectives

Yanyu Miao, Jianlin Ge, Longyi Zheng, Gang Liu

Small· Volume 21· Issue 22
Publisher page

Abstract

Abstract Cancer vaccines hold promise for tumor immunotherapy, with their success hinging on effective systems to boost anti‐tumor immunity. Biological membranes are not only a delivery vehicle but also a source of antigens and adjuvants, garnering growing interest in vaccine research. This review starts with an introduction to the composition and mechanisms of cancer vaccines and describes the sources, advantages/disadvantages, engineering strategies, and applications of these membrane‐based platforms for cancer vaccine development. This review also offers a critical analysis and discusses the further direction of the vaccine platform in view of clinical translation for tumor immunotherapy.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Immunotherapy and Immune Responses · RNA Interference and Gene Delivery · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory National Innovation Platform for Industry‐Education Integration in Vaccine Research Fujian Engineering Research Center of Molecular Theranostic Technology School of Public Health Xiamen University Xiamen 361102 China

School of Medicine Xiamen University Xiamen 361102 China

Funding

National Natural Science Foundation of China · National Postdoctoral Program for Innovative Talents · National Key Research and Development Program of China

References (100+)

Show source-provided references
1. 10.3322/caac.2176310.3322/caac.21763 ↗
2. 10.1002/cac2.1262710.1002/cac2.12627 ↗
3. 10.3322/caac.2183410.3322/caac.21834 ↗
4. 10.1016/S0140-6736(24)00757-810.1016/S0140-6736(24)00757-8 ↗
5. 10.1001/jamaoncol.2022.782610.1001/jamaoncol.2022.7826 ↗
6. 10.3389/fimmu.2019.0296510.3389/fimmu.2019.02965 ↗
7. Ma M. · Am. J. Transl. Res. · 2020 · 12 · 974
8. 10.1038/s41467-020-17670-y10.1038/s41467-020-17670-y ↗
9. 10.1016/j.trsl.2021.04.00810.1016/j.trsl.2021.04.008 ↗
10. 10.1002/smll.20200600010.1002/smll.202006000 ↗
11. 10.1038/s41573-018-0006-z10.1038/s41573-018-0006-z ↗
12. 10.1002/smll.20230873110.1002/smll.202308731 ↗
13. 10.1186/s12951-024-02590-610.1186/s12951-024-02590-6 ↗
14. 10.34133/research.047810.34133/research.0478 ↗
15. 10.1016/j.critrevonc.2024.10453610.1016/j.critrevonc.2024.104536 ↗
16. 10.1038/s41392-022-01270-x10.1038/s41392-022-01270-x ↗
17. 10.1186/s12943-023-01844-510.1186/s12943-023-01844-5 ↗
18. 10.1038/s41571-020-00460-210.1038/s41571-020-00460-2 ↗
19. 10.1038/s41541-019-0103-y10.1038/s41541-019-0103-y ↗
20. 10.1038/s41568-021-00346-010.1038/s41568-021-00346-0 ↗
21. 10.1186/s13045-022-01247-x10.1186/s13045-022-01247-x ↗
22. 10.1080/14760584.2021.198489010.1080/14760584.2021.1984890 ↗
23. 10.1016/j.cytogfr.2009.07.00410.1016/j.cytogfr.2009.07.004 ↗
24. 10.1038/317108b010.1038/317108b0 ↗
25. 10.1038/184291a010.1038/184291a0 ↗
26. Klein G. · Cancer Res. · 1968 · 28 · 625
27. 10.1126/science.175.4023.72010.1126/science.175.4023.720 ↗
28. 10.1038/253744a010.1038/253744a0 ↗
29. 10.1136/jitc-2020-00111910.1136/jitc-2020-001119 ↗
30. 10.1126/science.184070310.1126/science.1840703 ↗
31. 10.1038/nm0598-59410.1038/nm0598-594 ↗
32. 10.1186/1479-5876-3-1010.1186/1479-5876-3-10 ↗
33. Burch P. A. · Clin. Cancer Res. · 2000 · 6 · 2175
34. 10.1016/j.jhep.2017.05.01910.1016/j.jhep.2017.05.019 ↗
35. 10.1007/s40820-023-01125-210.1007/s40820-023-01125-2 ↗
36. 10.1177/030098581880914210.1177/0300985818809142 ↗
37. 10.3389/fimmu.2022.94004710.3389/fimmu.2022.940047 ↗
38. 10.1016/j.smim.2018.08.00110.1016/j.smim.2018.08.001 ↗
39. 10.1146/annurev.immunol.021908.13271510.1146/annurev.immunol.021908.132715 ↗
40. 10.1038/s41467-023-37328-910.1038/s41467-023-37328-9 ↗
41. 10.1016/j.jpha.2023.04.01210.1016/j.jpha.2023.04.012 ↗
42. 10.1016/j.bj.2024.10070210.1016/j.bj.2024.100702 ↗
43. 10.1038/s41573-021-00163-y10.1038/s41573-021-00163-y ↗
44. 10.1136/jitc-2023-00719810.1136/jitc-2023-007198 ↗
45. 10.3389/fimmu.2022.85777910.3389/fimmu.2022.857779 ↗
46. 10.1016/j.actbio.2018.11.02310.1016/j.actbio.2018.11.023 ↗
47. 10.1016/j.etap.2020.10340410.1016/j.etap.2020.103404 ↗
48. 10.1016/j.biopha.2023.11495410.1016/j.biopha.2023.114954 ↗
49. 10.1016/j.biopha.2023.11599210.1016/j.biopha.2023.115992 ↗
50. 10.1038/s41467-024-55751-410.1038/s41467-024-55751-4 ↗
51. 10.1016/j.jconrel.2024.12.00410.1016/j.jconrel.2024.12.004 ↗
52. 10.1021/acsnano.4c0506510.1021/acsnano.4c05065 ↗
53. 10.1126/science.aau697710.1126/science.aau6977 ↗
54. 10.1084/jem.183.3.116110.1084/jem.183.3.1161 ↗
55. 10.1186/s12943-019-0963-910.1186/s12943-019-0963-9 ↗
56. 10.1038/nrm.2017.12510.1038/nrm.2017.125 ↗
57. 10.1172/JCI8113510.1172/JCI81135 ↗
58. 10.1007/s00109-013-1020-610.1007/s00109-013-1020-6 ↗
59. 10.1039/D0TB01499K10.1039/D0TB01499K ↗
60. 10.1038/s41419-024-06494-z10.1038/s41419-024-06494-z ↗
61. 10.20892/j.issn.2095-3941.2022.045210.20892/j.issn.2095-3941.2022.0452 ↗
62. 10.1038/nri383710.1038/nri3837 ↗
63. 10.1038/s41467-021-22308-810.1038/s41467-021-22308-8 ↗
64. 10.1016/j.ijbiomac.2020.09.18710.1016/j.ijbiomac.2020.09.187 ↗
65. 10.1002/advs.20190017210.1002/advs.201900172 ↗
66. 10.1038/nnano.2012.21210.1038/nnano.2012.212 ↗
67. 10.1038/s41423-024-01203-410.1038/s41423-024-01203-4 ↗
68. 10.1038/s41598-024-53999-w10.1038/s41598-024-53999-w ↗
69. 10.1038/s41594-023-01170-w10.1038/s41594-023-01170-w ↗
70. 10.1016/j.jconrel.2022.06.02610.1016/j.jconrel.2022.06.026 ↗
71. 10.2217/nnm-2023-016410.2217/nnm-2023-0164 ↗
72. 10.1016/j.nantod.2024.10238310.1016/j.nantod.2024.102383 ↗
73. 10.1002/adma.20220892310.1002/adma.202208923 ↗
74. 10.1080/2162402X.2022.212769110.1080/2162402X.2022.2127691 ↗
75. 10.3390/polym1607093110.3390/polym16070931 ↗
76. 10.1080/17425247.2016.118248510.1080/17425247.2016.1182485 ↗
77. 10.1016/j.colsurfb.2023.11352010.1016/j.colsurfb.2023.113520 ↗
78. 10.1016/j.mtbio.2024.10114510.1016/j.mtbio.2024.101145 ↗
79. 10.1021/acsnano.1c0445610.1021/acsnano.1c04456 ↗
80. 10.1002/adma.20241136110.1002/adma.202411361 ↗
81. 10.1016/j.jconrel.2020.01.05410.1016/j.jconrel.2020.01.054 ↗
82. 10.1016/j.nantod.2020.10089610.1016/j.nantod.2020.100896 ↗
83. 10.1002/smtd.20200029110.1002/smtd.202000291 ↗
84. 10.1016/j.actbio.2017.11.00310.1016/j.actbio.2017.11.003 ↗
85. 10.1038/s41467-023-40886-710.1038/s41467-023-40886-7 ↗
86. 10.1038/s41565-023-01533-w10.1038/s41565-023-01533-w ↗
87. 10.1136/jitc-2021-00430910.1136/jitc-2021-004309 ↗
88. 10.1016/j.nantod.2020.10103810.1016/j.nantod.2020.101038 ↗
89. 10.1038/s41467-020-19061-910.1038/s41467-020-19061-9 ↗
90. 10.1002/advs.20200034610.1002/advs.202000346 ↗
91. 10.1016/j.biomaterials.2019.11975310.1016/j.biomaterials.2019.119753 ↗
92. 10.1016/j.ijbiomac.2023.12695210.1016/j.ijbiomac.2023.126952 ↗
93. 10.1002/mabi.20210031810.1002/mabi.202100318 ↗
94. 10.1016/j.jare.2021.07.00910.1016/j.jare.2021.07.009 ↗
95. 10.1002/adma.20240319910.1002/adma.202403199 ↗
96. 10.3390/biomedicines1004083810.3390/biomedicines10040838 ↗
97. 10.1038/nature1311810.1038/nature13118 ↗
98. 10.1021/nl404771g10.1021/nl404771g ↗
99. 10.1016/j.chemosphere.2020.12727910.1016/j.chemosphere.2020.127279 ↗
100. 10.1016/j.ultsonch.2022.10603210.1016/j.ultsonch.2022.106032 ↗