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journal article·2025-03Open access

Artificial Intelligence‐Enhanced Analysis of Genomic DNA Visualized with Nanoparticle‐Tagged Peptides under Electron Microscopy (Small 12/2025)

Priyannth Ramasami Sundharbaabu, Junhyuck Chang, Yunchul Kim, Youmin Shim, Byoungsang Lee, Chanyoung Noh, Sujung Heo, Seung Seo Lee, Sang‐Hee Shim, Kwang‐il Lim, Kyubong Jo, Jung Heon Lee

Small· Volume 21· Issue 12
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Source abstract

Abstract

DNA Visualization In article number 2405065, Byoungsang Lee, Kyubong Jo, Jung Heon Lee, and co-workers developed a novel staining method utilizing gold nanoparticle-tagged peptides, enabling genomic-scale, sequence-specific, and multi-conformational visualization of DNA molecules under an electron microscope. The stained DNA molecules undergo detailed structural and dimensional analysis through an artificial intelligence-enabled image analysis system. This comprehensive approach offers significant potential for applications in DNA sequence mapping and structural genomics.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques

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Affiliations

School of Advanced Materials Science and Engineering Sungkyunkwan University (SKKU) Suwon 16419 South Korea

Department of Chemistry & Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul 04107 South Korea

School of Chemistry and Chemical Engineering University of Southampton Southampton SO17 1BJ UK

Department of Chemistry Korea University Seoul 02841 South Korea

Department of Chemical and Biological Engineering Sookmyung Women's University Seoul 04312 South Korea

Department of MetaBioHealth Sungkyunkwan University (SKKU) Suwon 16419 South Korea

References

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