DataVXSmallPaper
journal article·2022-04

Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation (Small 17/2022)

Ondrej Sedlacek, Valentin Bardoula, Elina Vuorimaa‐Laukkanen, Lars Gedda, Katarina Edwards, Aurel Radulescu, Grigoriy A. Mun, Yong Guo, Junnian Zhou, Hongbo Zhang, Véronique Nardello‐Rataj, Sergey Filippov, Richard Hoogenboom

Small· Volume 18· Issue 17
Publisher page
Source abstract

Abstract

Amphiphilic Gradient Copolymers In article number 2106251, Richard Hoogenboom and co-workers provide an in-depth analysis of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. In addition to several interesting differences between the two copolymer architecture classes, it can be concluded that gradient copolymers provide stable nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Polymer Synthesis and Characterization · biodegradable polymer synthesis and properties · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Supramolecular Chemistry Group Department of Organic and Macromolecular Chemistry Ghent University Krijgslaan 281 S4 Ghent B‐9000 Belgium

Department of Physical and Macromolecular Chemistry Faculty of Science Charles University Hlavova, 2030 Prague 2 128 40 Czech Republic

Centrale Lille Université de Lille CNRS Université Artois UMR 8181‐UCCS‐Unité de Catalyse et Chimie du Solide Lille F‐59000 France

Tampere University of Technology Korkeakoulunkatu 7 Tampere 33720 Finland

Department of Chemistry –Ångström Laboratory Uppsala University Lägerhyddsvägen 1 Uppsala Sweden

Jülich Centre for Neutron Science (JCNS) at Heinz Maier‐Leibnitz Zentrum (MLZ) Forschungszentrum Jülich GmbH Lichtenbergstr. 1 85748 Garching Germany

Department of Chemistry & Technology of Organic Materials Polymers and Natural Compounds al Faraby Kazakh National University 71, al‐Faraby av. Almaty 050040 Republic of Kazakhstan

Department of Endocrinology Key Laboratory of National Health & Family Planning Commission for Male Reproductive Health National Research Institute for Family Planning Beijing 100081 China

Pharmaceutical Sciences Laboratory and Turku Bioscience Center of Åbo Akademi University and Turku Bioscience Turku 20520 Finland

Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation Medicine Beijing 100850 China

School of Pharmacy University of Reading Whiteknights Reading RG6 6DX UK

References

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