DNA Self‐Assembly Optimization by Betaine and Its Analogs
Source abstract
Abstract
Abstract The self‐assembly yield of DNA nanostructures can be exponentially lower with increasing structural complexity. Few optimizing strategies are available in the DNA nanotechnology field for the assembly yield improvement. Here, betaine and its analogs are applied as supplementary ingredients in DNA self‐assembly. Such a simple implementation results in effective yield improvement. Through a comprehensive investigation, a reliable yield improvement of two‐ to threefold is achieved for a number of DNA nanostructures with considerable complexity.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · DNA and Nucleic Acid Chemistry · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Life Sciences Tsinghua University Beijing 100084 China
Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China
BGI Research Shenzhen 518083 China
BGI Research Changzhou 213299 China
Guangdong Provincial Key Laboratory of Genome Read and Write BGI Research Shenzhen 518083 China
Funding
National Natural Science Foundation of China · National Key Research and Development Program of China
References (34)
Show source-provided references
1. 10.1016/0022-5193(82)90002-910.1016/0022-5193(82)90002-9 ↗
2. 10.1038/2899810.1038/28998 ↗
3. 10.1038/nature0458610.1038/nature04586 ↗
4. 10.1038/nature0659710.1038/nature06597 ↗
5. 10.1126/science.117425110.1126/science.1174251 ↗
6. 10.1038/nature0801610.1038/nature08016 ↗
7. 10.1038/nature0827410.1038/nature08274 ↗
8. 10.1126/science.122726810.1126/science.1227268 ↗
9. 10.1038/nature1107510.1038/nature11075 ↗
10. 10.1038/nature2464810.1038/nature24648 ↗
11. 10.1038/nature2465510.1038/nature24655 ↗
12. 10.1038/s41467-019-08647-710.1038/s41467-019-08647-7 ↗
13. 10.1038/s41565-022-01283-110.1038/s41565-022-01283-1 ↗
14. 10.1038/ncomms209510.1038/ncomms2095 ↗
15. 10.1002/smll.20170210010.1002/smll.201702100 ↗
16. 10.1002/smll.20230004010.1002/smll.202300040 ↗
17. 10.1038/s41565-023-01468-210.1038/s41565-023-01468-2 ↗
18. 10.1126/science.122991910.1126/science.1229919 ↗
19. 10.1021/nl401951210.1021/nl4019512 ↗
20. 10.1021/jacs.8b1035510.1021/jacs.8b10355 ↗
21. 10.1002/anie.20130361110.1002/anie.201303611 ↗
22. 10.1039/C6NR00835F10.1039/C6NR00835F ↗
23. 10.1021/ja410698u10.1021/ja410698u ↗
24. 10.1021/jp406647b10.1021/jp406647b ↗
25. 10.1021/bi00052a01910.1021/bi00052a019 ↗
26. 10.1093/nar/24.14.277410.1093/nar/24.14.2774 ↗
27. 10.1038/nrm381010.1038/nrm3810 ↗
28. 10.1038/ncomms986110.1038/ncomms9861 ↗
29. 10.3390/biom401023510.3390/biom4010235 ↗
30. 10.1093/nar/gkab61110.1093/nar/gkab611 ↗
31. 10.1073/pnas.93.20.1072910.1073/pnas.93.20.10729 ↗
32. 10.1073/pnas.25263339910.1073/pnas.252633399 ↗
33. 10.3390/molecules2521509910.3390/molecules25215099 ↗
34. Singh A. · J. Am. Chem. Soc. · 2023 · 145