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journal article·2023-05Open access

Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy (Small 20/2023)

Yuqi Xing, Feiyu Zhang, Panpan Ji, Mengying Wei, Chunhui Yin, Angang Yang, Guodong Yang, Jing Zhao

Small· Volume 19· Issue 20
Publisher pageOpen full text
Source abstract

Abstract

Engineered Extracellular Vesicles In article number 2204031, Jing Zhao, Guodong Yang, Angang Yang, and co-workers develop an extracellular vesicle-based GSDMD-N mRNA delivery system (EVTx), in which GSDMD-N mRNA is encapsulated inside the vesicle, HER2 antibody is displayed on the surface, and sonosensitizer Ce6 is incorporated into the membrane. When endocytosed by HER2+ cancer cells, EVTx efficiently induces pyroptosis and thus enhances cancer immunotherapy.
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Research context

OpenAlex topics: Extracellular vesicles in disease · Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The State Laboratory of Cancer Biology Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi'an Shaanxi 710032 China

Department of Cardiology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi 710032 China

The State Laboratory of Cancer Biology Department of Gastrointestinal Surgery Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an Shaanxi 710032 China

The State Laboratory of Cancer Biology Department of Immunology Fourth Military Medical University No. 169 Changlexi Road Xi'an Shaanxi 710032 China

References

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