Source abstract
Abstract
The formation of nanoaggregates makes a great difference to the improvement of photodynamic therapy (PDT) performance to some extent, but constructing stable aggregates with a clear structure is simultaneously a big challenge for us. Herein, just by electrostatic interaction, cationic 2PAHs and anionic FBA351, regarded as acceptor (A) and donor (D), respectively, are utilized to prepare stable aggregate of ionic‐bonds coupled polymer (ICP) with repeated “D–A” structure, which is fully characterized by nuclear magnetic resonance (NMR), time‐of‐flight mass spectrometry, X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Remarkably, aggregate ICP with multiple “D–A” structures showed enhanced photosensitization efficiency over its precursor 2PAHs and FBA351, which is in accord with the image‐guided photodynamic anticancer therapy. Such results not only offer a simple way to obtain stable aggregate but also give us a guideline to design efficient photosensitizers.
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Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Luminescence and Fluorescent Materials
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Affiliations
School of Materials Science and Engineering Center for Aggregation‐Induced Emission State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China
Department of Urology The First Affiliated Hospital of Soochow University 188 Shizi RD Suzhou 215006 China
Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong Shenzhen Guangdong 518172 China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province
References (24)
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