Source abstract
Abstract
Abstract The capture of circulating tumor cells (CTCs) by nanostructured substrate surface is a useful method for early diagnosis of cancer. At present, most methods used to improve the cell capture efficiency are based on changing substrate surface properties. However, there are still some gaps between these methods and practical applications. Here, a method is presented for improving cell capture efficiency from a different perspective, that is, changing the properties of the cells. Concretely, the mechanical properties of the cell membrane are changed by adding Cytochalasin D to soften the cell membrane. Furthermore, a corresponding theoretical model is proposed to explain the experimental results. It is found that cell softening can reduce the resistance of cell adhesion, which makes the adhesion ability stronger. The high‐efficiency capture of cells by softening the cell membrane provides a potential method to improve the detection performance of CTCs.
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Research context
OpenAlex topics: Microfluidic and Bio-sensing Technologies · Cancer Cells and Metastasis · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631 China
Guangdong Provincial Key Laboratory of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631 China
College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China
SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd. Qingyuan 511517 China
Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University Guangzhou 510631 China
Funding
National Natural Science Foundation of China
References (44)
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