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journal article·2023-04Open access

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis (Small 16/2023)

Yuan Zhu, Kunkun Yang, Yawen Cheng, Yaoshan Liu, Ranli Gu, Xuenan Liu, Hao Liu, Xiao Zhang, Yunsong Liu

Small· Volume 19· Issue 16
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Source abstract

Abstract

Cell-Free Therapies hBMMSC-apoVs can promote mesenchymal stem cell (MSC) osteogenesis and inhibit osteoclast formation in vitro and in vivo. The mechanisms include the release of miR1324, which inhibits the expression of the target gene SNX14, thereby activating the SMAD1/5 pathway in target cells. In article number 2205813, Xiao Zhang, Yunsong Liu, and co-workers suggest a therapeutic strategy for the treatment of bone loss, including bone tissue engineering through a cell-free approach.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Bone Metabolism and Diseases · Bone health and treatments · MicroRNA in disease regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Prosthodontics Peking University School and Hospital of Stomatology 22 Zhongguancun South Avenue Beijing 100081 China

National Center of Stomatology National Laboratory for Digital and Material Technology of Stomatology National Clinical Research Center for Oral Diseases Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing 100081 China

The Central Laboratory Peking University School and Hospital of Stomatology 22 Zhongguancun South Avenue Beijing 100081 China

References

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