Effect of Protein Adsorption on the Fluorescence of Ultrasmall Gold Nanoclusters

small 2012, 8, 661–665 The data published on page 663 in Figure 3 and Table 1 are imprecise due to the use of too high Au nanocluster concentration in the protein binding experiments. The corrected figure and table appear below: Consequently, the text on page 662 (right column) should read: Line 7: An excellent agreement was achieved by fitting the fluorescence intensity of Au NCs (F) as a function of HSA concentration ([HSA]) with equation (1) (Figure 3A), yielding KD = (0.08 ± 0.02) μM. Line 14: The Hill coefficient, n = 0.8 ± 0.1, is <1, suggesting anti-cooperative binding, i.e., the affinity decreases with progressing protein adsorption. Line 24: For lysozyme, we observed similar anti-cooperative binding to Au NCs as HSA, whereas transferrin and ApoE4 were observed to bind to Au NCs in a non-cooperative manner, with n = 1.0. Other contents and the conclusions of the paper are unaffected.