journal article·2017-11

A DNA Origami Mechanical Device for the Regulation of Microcosmic Structural Rigidity

Neng Wan, Zhouping Hong, Huading Wang, Xin Fu, Ziyue Zhang, Chao Li, Han Xia, Yan Fang, Maoteng Li, Yi Zhan, Xiangliang Yang

Small· Volume 13· Issue 41
Publisher page

Abstract

Abstract DNA origami makes it feasible to fabricate a tremendous number of DNA nanostructures with various geometries, dimensions, and functionalities. Moreover, an increasing amount of research on DNA nanostructures is focused on biological and biomedical applications. Here, the reversible regulation of microcosmic structural rigidity is accomplished using a DNA origami device in vitro. The designed DNA origami monomer is composed of an internal central axis and an external sliding tube. Due to the external tube sliding, the device transforms between flexible and rigid states. By transporting the device into the liposome, the conformational change of the origami device induces a structural change in the liposome. The results obtained demonstrate that the programmed DNA origami device can be applied to regulate the microcosmic structural rigidity of liposomes. Because microcosmic structural rigidity is important to cell proliferation and function, the results obtained potentially provide a foundation for the regulation of cell microcosmic structural rigidity using DNA nanostructures.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Modular Robots and Swarm Intelligence · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Education Base of Biological Science College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Innovation Base of Life Science and Technology Qiming College Huazhong University of Science and Technology Wuhan 430074 P. R. China

Bei Shizhang Advanced Class of Life Science Research co‐founded by Huazhong University of Science and Technology & Institute of Biophysics Chinese Academy of Sciences & University of Chinese Academy of Sciences Wuhan 430074 P. R. China

Department of Biotechnology College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Department of Bioinformatics College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Department of Nanomedicine and Biopharmaceutics College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Student Affairs Office, College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

Funding

National Natural Science Foundation of China · Henan University of Science and Technology

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