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journal article·2022-08Open access

A Synthetic Minimal Beating Axoneme

Isabella Guido, Andrej Vilfan, Kenta Ishibashi, Hitoshi Sakakibara, Misaki Shiraga, Eberhard Bodenschatz, Ramin Golestanian, Kazuhiro Oiwa

Small· Volume 18· Issue 32
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Source abstract

Abstract

Abstract Cilia and flagella are beating rod‐like organelles that enable the directional movement of microorganisms in fluids and fluid transport along the surface of biological organisms or inside organs. The molecular motor axonemal dynein drives their beating by interacting with microtubules. Constructing synthetic beating systems with axonemal dynein capable of mimicking ciliary beating still represents a major challenge. Here, the bottom‐up engineering of a sustained beating synthoneme consisting of a pair of microtubules connected by a series of periodic arrays of approximately eight axonemal dyneins is reported. A model leads to the understanding of the motion through the cooperative, cyclic association–dissociation of the molecular motor from the microtubules. The synthoneme represents a bottom‐up self‐organized bio‐molecular machine at the nanoscale with cilia‐like properties.
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Research context

Nanomaterials

OpenAlex topics: Micro and Nano Robotics · Microtubule and mitosis dynamics · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Max Planck Institute for Dynamics and Self‐Organization (MPIDS) 37077 Göttingen Germany

Jožef Stefan Institute Ljubljana 1000 Slovenia

Graduate School of Frontier Biosciences Osaka University Osaka 5650871 Japan

Center for Information and Neural Networks (CiNet) National Institute of Information and Communications Technology Osaka 565‐0871 Japan

Advanced ICT Research Institute National Institute of Information and Communications Technology Kobe 651‐2492 Japan

Graduate School of Life Science University of Hyogo Hyogo 678‐1297 Japan

Institute for Dynamics of Complex Systems Georg‐August‐University Göttingen 37073 Göttingen Germany

Laboratory of Atomic and Solid‐State Physics Cornell University Ithaca NY 14853 USA

Rudolf Peierls Centre for Theoretical Physics University of Oxford Oxford OX1 3PU UK

Funding

Bundesministerium für Bildung und Forschung · Max-Planck-Gesellschaft · Volkswagen Foundation · Javna Agencija za Raziskovalno Dejavnost RS · Takeda Science Foundation

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