Upconversion: Red‐Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near‐Infrared Excitation (Small 11/2013)

A cooperative therapeutic system combining doxorubicin-induced chemotherapy and chlorine 6-triggered photodynamic therapy (PDT) based on upconverting nanoparticles (UCNPs) is designed on page 1929. In this system, the therapeutic efficacy is manageable since the doxorubicin release is sensitive to the environmental pH values and the PDT efficiency can be fine-tuned by the incident near-infrared irradiation. Importantly, the combinational therapeutic system exhibits a greatly enhanced efficacy relative to the individual cancer therapies.