Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition

Chiral recognition plays an important role for biomacromolecules involved self-assembly and further affects their biological functions. Herein, it is demonstrated that two chiral metal complexes can enantioselectively bind with Aβ15-20, leading to the formation of different self-assembled nanostructures. With the ability of both metal complexes and Aβ15-20 to inhibit Aβ1-40 aggregation, the NiM@P hybrid particles can act as bifunctional Aβ inhibitors. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.