Engineering Gadolinium‐Integrated Tellurium Nanorods for Theory‐Oriented Photonic Hyperthermia in the NIR‐II Biowindow

Abstract Near‐infrared (NIR) light‐triggered hyperthermia has exhibited promising prospects in oncology therapy due to the unique merits including minimal invasiveness, monitorable, excellent therapeutic effect, and negligible side effects. Especially, the second NIR biowindow (NIR‐II, 1000–1700 nm) with less absorbance and scattering by skin tissue, and deep tissue penetration, has received extensive attention for photonic hyperthermia. Unfortunately, the dissatisfactory photothermal conversion efficiency (PCE) and cumbersome preparation process of photo‐driven heat conversion nanomaterials seriously hamper the future clinical application. To combat the aforementioned challenges, high imaging performance and desired therapeutic outcome 1D nanorods are constructed based on gadolinium‐integrated tellurium nanorods (Te–Gd). In this system, magnetic resonance (MR) imaging and X‐ray computed tomography (CT) imaging‐guided photonic hyperthermia can be easily implemented in cooperation with Te–Gd. Importantly, Te–Gd possesses high PCE (41%) in the NIR‐II biowindow because the transition of the excited electron can easily occur from the valence band (VB) to the conduction band (CB) on (1 0 1) and (1 0 2) crystal planes. Furthermore, the distinctive photostability, high tumor accumulation, as well as low systemic adverse effects of Te–Gd guarantee the potential in the clinic.