journal article·2016-01-26Open access

Tools for the Microbiome: Nano and Beyond

Julie S. Biteen, Paul C. Blainey, Zoe G. Cardon, Miyoung Chun, George M. Church, Pieter C. Dorrestein, Scott E. Fraser, Jack A. Gilbert, Janet K. Jansson, Rob Knight, Jeff F. Miller, Aydogan Ozcan, Kimberly A. Prather, Stephen R. Quake, Edward G. Ruby, Pamela A. Silver, Sharif Taha, Ger van den Engh, Paul S. Weiss, Gerard C. L. Wong, Aaron T. Wright, Thomas D. Young

ACS Nano· Volume 10· Issue 1

Abstract

The microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. These technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Biosensors and Analytical Detection · Gut microbiota and health · Cell Image Analysis Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

Department of Biological Engineering, Massachusetts Institute of Technology, and Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02138, United States

The Ecosystems Center, Marine Biological Laboratory, Woods Hole, Massachusetts 02543-1015, United States

The Kavli Foundation, Oxnard, California 93030, United States

Wyss Institute for Biologically Inspired Engineering and Biophysics Program, Harvard University, Boston, Massachusetts 02115, United States

Translational Imaging Center, University of Southern California, Molecular and Computational Biology, Los Angeles, California 90089, United States

Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, Illinois 60439, United States

Department of Ecology and Evolution and Department of Surgery, University of Chicago, Chicago, Illinois 60637, United States

Earth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States

Kewalo Marine Laboratory, University of Hawaii-Manoa, Honolulu, Hawaii 96813, United States

Center for Marine Cytometry, Concrete, Washington 98237, United States

Instituto Milenio de Oceanografía, Universidad de Concepción, Concepción, Chile

Funding

Office of Naval Research · U.S. Department of Energy · Kavli Foundation

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