article·2015-01-22Open access

Supramolecular Nanosubstrate-Mediated Delivery for Reprogramming and Transdifferentiation of Mammalian Cells

Shuang Hou, Jin‐sil Choi, Kuan‐Ju Chen, Yang Zhang, Jinliang Peng, Mitch A. Garcia, Juehua Yu, Kaushali Thakore-Shah, Tracy Ro, Jie‐Fu Chen, Parham Peyda, Guoping Fan, April D. Pyle, Hao Wang, Hsian‐Rong Tseng

Abstract

Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.
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Research context

OpenAlex topics: RNA Interference and Gene Delivery · Graphene and Nanomaterials Applications · Pluripotent Stem Cells Research

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