Liposome Destabilization by a 2,7‐Diazapyrenium Derivative Through Formation of Transient Pores in the Lipid Bilayer
Source abstract
Abstract
Abstract The effect of the luminescent heteroaromatic electron acceptor N,N′‐dimethyl‐2,7‐diazapyrenium dichloride (DM‐DAP2+) on the stability of 1‐palmitoyl‐2‐oleoylphosphatydilcholine (POPC) liposomes is determined on the basis of the rate of release of different fluorescent probes entrapped within the liposome. The experiments show that DM‐DAP2+ exerts a substantial destabilizing action on the liposomal bilayer, particularly at low concentrations. Molecular dynamics simulations suggest that the activity of DM‐DAP2+ is related to its tendency to surround itself with water molecules, conceivably favoring the formation of transient pores across the bilayer.
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Research context
OpenAlex topics: Lipid Membrane Structure and Behavior · RNA Interference and Gene Delivery · Nanopore and Nanochannel Transport Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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