Cancer Therapy: Development of Novel Tumor‐Targeted Theranostic Nanoparticles Activated by Membrane‐Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy (Small 3/2014)

Celina Ansari; Grigory A. Tikhomirov; Su Hyun Hong; Robert A. Falconer; Paul M. Loadman; Jason H. Gill; Rosalinda Castaneda; Florette K. Hazard; Ling Tong; Olga D. Lenkov; Dean W. Felsher; Jianghong Rao; Heike E. Daldrup‐Link

doi:10.1002/smll.201470016

journal article·2014-02Open access

Cancer Therapy: Development of Novel Tumor‐Targeted Theranostic Nanoparticles Activated by Membrane‐Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy (Small 3/2014)

Celina Ansari, Grigory A. Tikhomirov, Su Hyun Hong, Robert A. Falconer, Paul M. Loadman, Jason H. Gill, Rosalinda Castaneda, Florette K. Hazard, Ling Tong, Olga D. Lenkov, Dean W. Felsher, Jianghong Rao, Heike E. Daldrup‐Link

Small· Volume 10· Issue 3

Publisher page Open full text

Source abstract

Abstract

Cancer cells overexpress matrix-type metalloproteinases (MMPs, shown as pacmen). MMPs cleave the peptide linker connecting anticancer prodrug to the dextran coated magnetic nanoparticle. After the cleavage, the drug becomes toxic (active drug shown in purple). As J. Rao, H. E. Daldrup-Link, and co-workers describe on page 566, this tumor specific drug release reduces the side-effects of cancer therapy. The magnetic core of the nanoparticles allows for MRI monitoring of their distribution in the body.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Molecular Imaging Program at Stanford and Department of Radiology Stanford University 725 Welch Road, Rm 1665 Stanford CA 94305–5614 USA

Institute of Cancer Therapeutics, School of Life Sciences University of Bradford Richmond Road Bradford BD7 1DP UK

School of Medicine, Pharmacy and Health Durham University Queens Campus Stockton‐on‐Tees TS17 6BH UK

Department of Pathology Stanford University 300 Pasteur Drive Stanford CA 94305 USA

Division of Oncology, Department of Medicine Stanford University 269 Campus Drive, CCSR 1105 Stanford CA 94305 USA

Molecular Imaging Program at Stanford Stanford University 725 Welch Road, Rm 1665 Stanford CA 94305–5614 USA

References

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