journal article·2018-07Open access

Bioimaging: Dual‐Modal NIR‐Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid‐β Species In Vivo (Small 28/2018)

Yinhui Li, Di Xu, Hei‐Nga Chan, Chung‐Yan Poon, See‐Lok Ho, Hung‐Wing Li, Man Shing Wong

Small· Volume 14· Issue 28

Abstract

In article number 1800901, Hung-Wing Li, Man-Shing Wong, and co-workers report a smart NIR/MR dual-modal nano-probe for in vivo imaging of β-amyloid in a Alzheimer's Disease transgenic mouse model. This nanoparticle-based probe is not only non-radiative and non-toxic, but also highly blood brain barrier permeable and neuroprotective against Aβ induced toxicities, suggesting a great potential for early detection and diagnosis of Alzheimer's disease in humans.
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Research context

OpenAlex topics: Alzheimer's disease research and treatments · Neurological Disease Mechanisms and Treatments

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Affiliations

Department Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry Application of Ministry of Education College of Chemistry Xiangtan University Xiangtan 411105 China

Department of Chemistry Hong Kong Baptist University Kowloon Tong Hong Kong SAR China

References

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