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journal article·2016-04

Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification

Fen Xu, Tianyi Kang, Jie Deng, Junli Liu, Xiaolei Chen, Yuan Wang, Liang Ouyang, Ting Du, Hong Tang, Xiaoping Xu, Shaochen Chen, Yanan Du, Yujun Shi, Zhiyong Qian, Yuquan Wei, Hongxin Deng, Maling Gou

Small· Volume 12· Issue 15
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Source abstract

Abstract

Extracorporeal devices have great promise for cleansing the body of virulence factors that are caused by venomous injuries, bacterial infections, and biological weaponry. The clinically used extracorporeal devices, such as artificial liver‐support systems that are mainly based on dialysis or electrostatic interaction, are limited to remove a target toxin. Here, a liver‐mimetic device is shown that consists of decellularized liver scaffold (DLS) populated with polydiacetylene (PDA) nanoparticles. DLS has the gross shape and 3D architecture of a liver, and the PDA nanoparticles selectively capture and neutralize the pore‐forming toxins (PFTs). This device can efficiently and target‐orientedly remove PFTs in human blood ex vivo without changing blood components or activating complement factors, showing potential application in antidotal therapy. This work provides a proof‐of‐principle for blood detoxification by a nanoparticle‐activated DLS, and can lead to the development of future medical devices for antidotal therapy.
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Research context

Nanomaterials

OpenAlex topics: Polydiacetylene-based materials and applications · RNA Interference and Gene Delivery · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu 610041 China

State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Center of Infectious Diseases West China Hospital Sichuan University Chengdu 610041 China

West China School of Pharmacy Sichuan University Chengdu 610041 P. R. China

Department of NanoEngineering University of California San Diego CA 92093 USA

Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China

Laboratory of Pathology West China Hospital Sichuan University Key Laboratory of Transplant Engineering and Immunology NHFPC West China Hospital Sichuan University Chengdu 610041 China

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