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journal article·2007-10

Using Magnetic Force to Enhance Immune Response to DNA Vaccine

Xian‐Feng Zhou, Bin Liu, Xiang‐Hui Yu, Xiao Zha, Xi‐Zhen Zhang, Xue‐Yun Wang, Ying‐Hua Jin, Yong‐Ge Wu, Chun‐Lai Jiang, Yue Chen, Yan Chen, Ya‐Ming Shan, Jun‐Qiu Liu, Wei Kong, Jia‐Cong Shen

Small· Volume 3· Issue 10
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Source abstract

Abstract

The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Immunotherapy and Immune Responses · RNA Interference and Gene Delivery · Virus-based gene therapy research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (24)

Show source-provided references
1. 10.1038/nm88110.1038/nm881 ↗
2. 10.1016/S0169-409X(98)00048-910.1016/S0169-409X(98)00048-9 ↗
3. Jiao S. · Hum. Gene Ther. · 1992 · 3
4. Wolff J. A. · J. Cell Sci. · 1992 · 103
5. 10.1038/sj.gt.330162410.1038/sj.gt.3301624 ↗
6. 10.1002/jgm.56910.1002/jgm.569 ↗
7. Gupta P. K. · 1993 · 71
8. 10.1038/sj.gt.330090010.1038/sj.gt.3300900 ↗
9. 10.1089/hum.1996.7.12-143710.1089/hum.1996.7.12-1437 ↗
10. Kass‐Eisler A. · Gene Ther. · 1996 · 3 · 154
11. H.Pilgrimm Superparamagnetic particles process for producing the same and their use.1999 US Patent No.5 9161 539; Silica Gel Gmbh.
12. 10.1021/bc980125h10.1021/bc980125h ↗
13. 10.1016/S0928-0987(00)00166-410.1016/S0928-0987(00)00166-4 ↗
14. Dupuis M. · J. Immunol. · 2000 · 165
15. 10.1038/3504610810.1038/35046108 ↗
16. 10.1038/nature0187610.1038/nature01876 ↗
17. 10.1089/hum.1994.5.1-1110.1089/hum.1994.5.1-11 ↗
18. 10.1016/0014-5793(93)80508-R10.1016/0014-5793(93)80508-R ↗
19. 10.1016/j.bbrc.2005.10.11110.1016/j.bbrc.2005.10.111 ↗
20. Doe B. · Proc. Natl. Acad. Sci. USA. · 1996 · 93
21. 10.1016/S1074-7613(00)80149-110.1016/S1074-7613(00)80149-1 ↗
22. 10.1038/356152a010.1038/356152a0 ↗
23. Widera G. · J. Immunol. · 2000 · 164
24. 10.1006/jcis.1996.064710.1006/jcis.1996.0647 ↗