Hybridization‐Induced “Off‐On” 19F‐NMR Signal Probe Release from DNA‐Functionalized Gold Nanoparticles
Source abstract
Abstract
Fluorine-19-DNA-functionalized gold nanoparticles (19F-DNA AuNPs) are demonstrated to provide a 19F-NMR off–on switch in response to target-specific DNA hybridization events. AuNP-bound 19F-DNA produces a low intensity signal that is undetectable above background. Upon complementary DNA hybridization and subsequent19F-DNA release, the 19F-NMR signal becomes detectable. This method has the potential to be used both in vitro and in vivo to non-invasively detect and image specific nucleic acid binding events of interest.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · DNA and Nucleic Acid Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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