DataVXSmallPaper
journal article·2024-10

Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti‐Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus (Small 40/2024)

Feng Zhou, Muchao Chen, Yufan Qian, Kai Yuan, Xuequan Han, Weishan Wang, Jiong Jiong Guo, Qian Chen, Bin Li

Small· Volume 20· Issue 40
Publisher page
Source abstract

Abstract

Osteoarthritis In article number 2400542, Feng Zhou, Qian Chen, Bin Li, and co-workers present a hyaluronan synthase 2-encoding lentivirus-loaded dexamethasone sodium phosphate hydrogel (HAS2@DexP-Gel). The hydrogel enhances endogenous hyaluronan production, reduces synovial inflammation, and delays cartilage degeneration. This research introduces a novel combinatorial nanotherapy approach for treating osteoarthritis.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Proteoglycans and glycosaminoglycans research · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedic Surgery The First Affiliated Hospital Medical 3D Printing Center Orthopedic Institute School of Biology & Basic Medical Sciences Suzhou Medical College Soochow University Suzhou Jiangsu 215000 P. R. China

Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Soochow University Suzhou Jiangsu 215123 P. R. China

Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 P. R. China

Department of Orthopaedics Qilu Hospital of Shandong University Shandong University Center for Orthopaedics Advanced Medical Research Institute Cheeloo College of Medicine Shandong University Jinan Shandong 250012 P. R. China

Department of Orthopaedic Surgery The First Affiliated Hospital Shihezi University School of Medicine Shihezi Xinjiang 832099 P. R. China

References

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