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journal article·2025-10

Silver Nanoparticles and Houttuynin Sodium‐Based Fibrous Poly(L‐lactide‐co‐glycolide)/Gelatin‐Based Dressings for Infectious Wound Healing

Xinyuan Zhao, Ziang Geng, Weiying Zhang, Muhammad Shafiq, Siyuan Wu, Zhengchao Yuan, Yun Qian, Peng Li, Yanbiao Wang, Shichao Jiang

Small· Volume 21· Issue 39
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Source abstract

Abstract

Abstract Bacterial infections present debilitating challenges for skin repair, particularly in managing complex microbial colonization and persistent inflammation that delay healing. To address this clinical gap, a dual‐functional electrospun dressing (PG@AgH) was developed by incorporating silver nanoparticles (Ag NPs) and houttuynin sodium (H) into poly(L‐lactide‐co‐glycolide)/gelatin (PG) fibers. Compared to conventional dual‐agent systems, PG@AgH achieves spatiotemporally controlled release. Ag NPs provide rapid antibacterial action against multidrug‐resistant pathogens (e.g., S. aureus, E. coli), while H sustains anti‐inflammatory modulation through macrophage polarization regulation. In vitro studies confirmed cytocompatibility and broad‐spectrum antimicrobial efficacy against bacterial (S. aureus, E. coli) and fungal (C. albicans) strains. Moreover, the PG@AgH dressings promoted rapid wound closure, enhanced collagen deposition, and reduced bacterial load at the wound site in S. aureus‐infected full‐thickness excisional defect model in rats. Taken together, this multifunctional approach overcomes the limitations of single‐mechanism dressings, offering a clinically translatable strategy for infectious wound management.
Source: crossref · Quality: baseline

Research context

NanomaterialsMaterials processing

OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Planarian Biology and Electrostimulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China

Health Management Center Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021 P. R. China

Innovation Center of NanoMedicine (iCONM) Kawasaki Institute of Industrial Promotion Kawasaki 210‐0821 Japan

College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 P. R. China

National Center for Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 P. R. China

Department of Orthopedic Trauma Binzhou Medical University Hospital Binzhou Shandong 256603 P. R. China

Department of Orthopedics the Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences) Jinan 250031 P. R. China

Funding

Natural Science Foundation of Shandong Province

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