Supramolecular Nanoplatforms with Activable Ultrasound and Magnetic Resonance Imaging for Cancer Diagnosis and Therapy

Abstract Excellent multifunctional platforms for cancer diagnosis and treatment are highly desirable. Herein, multifunctional nanocomposites are constructed by utilizing Mn ²⁺ to coordinate to the imidazole moiety anchored on CuO ₂ nanoparticles through cyclodextrin‐adamantane interaction. The encapsulated CuO ₂ nanoparticles (NPs) can generate hydrogen peroxide (H ₂ O ₂ ) at tumor sites under acidic conditions upon decomposition, which is further turned into oxygen (O ₂ ) under Mn ²⁺ catalysis, facilitating both ultrasound and magnetic resonance imaging (MRI). Moreover, the proposed nanomedicine enhances reactive oxygen species (ROS) generation and depletes glutathione (GSH), leading to increased lipid peroxidation (LPO) and effective ferroptosis‐mediated cancer therapy. Such a strategy presents a promising approach for the development of theranostics for imaging‐guided tumor therapy.