Enhanced Delivery of Photothermal Gelatin Nanoparticle for Redox Balanced Nanocatalytic Tumor Chemotherapy

Abstract Nanocatalytic platforms are promising in cancer therapeutics via combining multiple treatments, which can be leveraged through the metabolic dysfunction in cancer progression. However, the lack of effective tumor delivery platforms hampers this approach. Here, a gelatin‐based platform is designed that is preloaded with gold nanoparticles and photothermal polypyrrole (GNPs@AuNPs‐PPy) with an acid‐induced doping enhancement. Benefiting from the tumor associated overexpression of H₂O₂, peroxidase‐like Au nanoparticles induce a burst of oxidative reactive oxygen species in the local tumor microenvironment (TME). Subsequent orchestration of redox surroundings recruits immune cells, showcasing an effective antineoplastic pathway. Under near infrared light (NIR) irradiation, nanohybrids exhibit dual pH/NIR enhanced drug release within the TME, while allowing for multimodal imaging‐guided theranostics. Leveraging this modality, GNPs@AuNPs‐PPy delivers quercetin (a natural antitumor mediator) in TME, boosting anti‐tumor therapy. The gelatin‐mediated nanomedicine provides an alternative platform for combinatorial dynamic antitumor treatment.