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journal article·2023-12Open access

Engineered Extracellular Vesicles to Enhance Antigen Presentation for Boosting Light‐Driven Tumor Immunotherapy (Small 49/2023)

Xuyu Li, Shuaicheng He, Ban Luo, Puze Li, Xue Chen, Meichan Wu, Cheng Song, Chao Liu, Tian Yang, Xiaojuan Zhang, Xiangliang Yang, Jun Hu

Small· Volume 19· Issue 49
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Source abstract

Abstract

Engineered Extracellular Vesicles Extracellular vesicles (EVs)-based tumor immunotherapy has usually suffered from the limited cross presentation of tumor-associated antigen by dendritic cells (DCs). In article number 2303541, Jun Hu, Xiangliang Yang, and co-workers propose a straightforward engineering strategy to construct heat shock proteins 70 (HSP70) highly expressed EVs, which could capture tumor related antigens through the C-terminal polypeptide binding domain of HSP70 molecules and then stimulate the maturation of DCs via binding to the surface receptors of DCs.
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Research context

OpenAlex topics: Extracellular vesicles in disease · Nanoplatforms for cancer theranostics · Ferroptosis and cancer prognosis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Engineering Research Center for Nanomedicine College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Department of Ophthalmology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Department of Ophthalmology Wenchang People's Hospital Haikou 571321 China

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Hubei Jiangxia Laboratory Wuhan 430200 China

References

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