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journal article·2024-09

Vanadium Single Atoms Embedded in MoS2 Enabled Gut‐Brain Axis Neurotransmitter Detection at pM Levels

Linxuan Sun, Hengyue Xu, Yichao Bai, Liang Chang, Jianxiang Gao, Mingchuang Zhao, Arthur Tran Huang, Lan Ma, Yu Lei, Feiyu Kang, Mauricio Terrones

Small· Volume 20· Issue 39
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Source abstract

Abstract

Abstract The detection of monoamine neurotransmitters is of paramount importance as the neurotransmitters are the chemical messengers regulating the gut‐brain axis (GBA). It requires real‐time, ultrasensitive, and selective sensing of the neurotransmitters in the gastric/intestinal fluid. However, multi‐components present in the gastric/intestinal fluid make sensing challenging to achieve in terms of ultra‐high sensitivity and selectivity. Herein, an approach is introduced to utilize vanadium single atom catalytic (SAC) centers in van der Waals MoS2 (V‐MoS2) to selectively detect real‐time serotonin (5‐HT) in artificial gastric/intestinal fluid. The synergetic effect of V‐SACs and the surface S‐bonds on the MoS2 surface, enables an extremely wide range of 5‐HT detection (from 1 pM to 100 µM), with optimum selectivity and interference resistance. By combining density functional theory calculations and scanning transmission electron microscopy, it is concluded that the V‐SACs embedded in the MoS2 network create active sites that greatly facilitate the charge exchange between the material and the 5‐HT molecules. This result allows the 5‐HT detection in GBA studies to be more reliable, and the material tunability provides a general platform to achieve real‐time and multi‐component detection of other monoamine neurotransmitters in GBA such as dopamine and norepinephrine.
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Research context

Catalysis & surfaces

OpenAlex topics: Electrochemical sensors and biosensors · Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Materials Research, Center of Double Helix Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 P. R. China

Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 P. R. China

Institute of Materials Research Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen Guangdong 518055 P. R. China

Shenzhen All‐Solid‐State Lithium Battery Electrolyte Engineering Research Center and Shenzhen Geim Graphene Center Institute of Materials Research (IMR) Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 P. R. China

Laboratory of Advanced Materials School of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. China

Department of Physics Department of Chemistry Department of Materials Sciences Center for 2‐Dimensional and Layered Materials The Pennsylvania State University University Park PA 16802 USA

Research Initiative for Supra‐Materials Shinshu University Nagano 380‐8553 Japan

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