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journal article·2024-05-09Open access

Mitochondria‐Regulated Information Processing Nanosystem Promoting Immune Cell Communication for Liver Fibrosis Regression

Tingting Che, Xiaopeng Yang, Yuanyuan Zhang, Yin Zheng, Yufei Zhang, Xinge Zhang, Zhongming Wu

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Abstract

Abstract Liver fibrosis is a coordinated response to tissue injury that is mediated by immune cell interactions. A mitochondria‐regulated information‐processing (MIP) nanosystem that promotes immune cell communication and interactions to inhibit liver fibrosis is designed. The MIP nanosystem mimics the alkaline amino acid domain of mitochondrial precursor proteins, providing precise targeting of the mitochondria. The MIP nanosystem is driven by light to modulate the mitochondria of hepatic stellate cells, resulting in the release of mitochondrial DNA into the fibrotic microenvironment, as detected by macrophages. By activating the STING signaling pathway, the developed nanosystem‐induced macrophage phenotype switches to a reparative subtype (Ly6Clow) and downstream immunostimulatory transcriptional activity, fully restoring the fibrotic liver to its normal tissue state. The MIP nanosystem serves as an advanced information transfer system, allowing precise regulation of trained immunity, and offers a promising approach for effective liver fibrosis immunotherapy with the potential for clinical translation.
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Research context

Nanomaterials

OpenAlex topics: Mitochondrial Function and Pathology · Molecular Communication and Nanonetworks · ATP Synthase and ATPases Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

NHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology Tianjin Medical University Tianjin 300134 China

Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Tianjin 300134 China

Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong 250021 China

Jinan Key Laboratory of Translational Medicine on Metabolic Diseases Shandong Institute of Endocrine and Metabolic Diseases Endocrine and Metabolic Diseases Hospital of Shandong First Medical University Jinan Shandong 250012 China

Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Tianjin Key Laboratory of functional polymer materials, College of Chemistry Nankai University Tianjin 300071 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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