journal article·2024-08Open access

Mesoporous Gold: Substrate‐Dependent Growth Dynamics, Strain Accumulation, and Electrocatalytic Activity for Biosensing

Hyeongyu Park, Mostafa Kamal Masud, Aditya Ashok, Minjun Kim, Md Abdul Wahab, Jun Zhou, Yukana Terasawa, Carlos Salomon Gallo, Nam‐Trung Nguyen, Md Shahriar A. Hossain, Yusuke Yamauchi, Yusuf Valentino Kaneti

Small· Volume 20· Issue 35

Abstract

Abstract Understanding the growth of mesoporous crystalline materials, such as mesoporous metals, on different substrates can provide valuable insights into the crystal growth dynamics and the redox reactions that influence their electrochemical sensing performance. Herein, it is demonstrated how the amorphous nature of the glass substrate can suppress the typical <111> oriented growth in mesoporous Au (mAu) films. The suppressed <111> growth is manifested as an accumulation of strain, leading to the generation of abundant surface defects, which are beneficial for enhancing the electrochemical activity. The fine structuring attained enables dramatically accelerated diffusion and enhances the electrochemical sensing performance for disease‐specific biomolecules. As a proof‐of‐concept, the as‐fabricated glass‐grown mAu film demonstrates high sensitivity in electrochemical detection of SARS‐CoV‐2‐specific RNA with a limit of detection (LoD) as low as 1 attomolar (aM).
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Electrochemical Analysis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensland Brisbane QLD 4072 Australia

School of Mechanical and Mining Engineering Faculty of Engineering, Architecture, and Information Technology (EAIT) The University of Queensland Brisbane QLD 4072 Australia

Energy and Process Engineering Laboratory School of Mechanical Medical and Process Engineering Faculty of Science Queensland University of Technology 2 George Street Brisbane QLD 4000 Australia

School of Information and Communication Technology Griffith University Brisbane QLD 4072 Australia

Faculty of Advanced Science and Technology Kumamoto University 2‐39‐1 Chuo‐ku, Kurokami Kumamoto‐shi Kumamoto 860–8555 Japan

Translational Extracellular Vesicles in Obstetrics and Gynae‐Oncology Group and UQ Centre for Extracellular Vesicle Nanomedicine University of Queensland Centre for Clinical Research Faculty of Medicine The University of Queensland Brisbane QLD 4029 Australia

Queensland Micro‐ and Nanotechnology Centre (QMNC) Griffith University Nathan Campus QLD 4111 Australia

Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464–8603 Japan

Department of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 South Korea

Funding

National Health and Medical Research Council · Exploratory Research for Advanced Technology · Advance Queensland

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