Permanent Anticoagulation Blood‐Vessel by Mezzo‐Sized Double Re‐Entrant Structure

Abstract Having a permanent omniphobicity on the inner surface of the tube can bring enormous advantages, such as reducing resistance and avoiding precipitation during mass transfer. For example, such a tube can prevent blood clotting when delivering blood composed of complex hydrophilic and lipophilic compounds. However, it is very challenging to fabricate micro and nanostructures inside a tube. To overcome these, a wearability and deformation‐free structural omniphobic surface is fabricated. The omniphobic surface can repel liquids by its “air‐spring” under the structure, regardless of surface tension. Furthermore, it is not lost an omniphobicity under physical deformation like curved or twisted. By using these properties, omniphobic structures on the inner wall of the tube by the “roll‐up” method are fabricated. Fabricated omniphobic tubes still repels liquids, even complex liquids like blood. According to the ex vivo blood tests for medical usage, the tube can reduce thrombus formation by 99%, like the heparin‐coated tube. So, the surface will soon replace typical coating‐based medical surfaces or anticoagulation blood vessels.