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journal article·2022-12Open access

Targeted Suppression of Peptide Degradation in Ag‐Based Surface‐Enhanced Raman Spectra by Depletion of Hot Carriers

Xiaobin Yao, Christiane Höppener, Henrik Schneidewind, Stephanie Hoeppener, Zian Tang, Axel Buchholz, Annika König, Selene Mogavero, Marco Diegel, Jan Dellith, Andrey Turchanin, Winfried Plass, Bernhard Hube, Volker Deckert

Small· Volume 18· Issue 52
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Source abstract

Abstract

Abstract Sample degradation, in particular of biomolecules, frequently occurs in surface‐enhanced Raman spectroscopy (SERS) utilizing supported silver SERS substrates. Currently, thermal and/or photocatalytic effects are considered to cause sample degradation. This paper establishes the efficient inhibition of sample degradation using iodide which is demonstrated by a systematic SERS study of a small peptide in aqueous solution. Remarkably, a distinct charge separation‐induced surface potential difference is observed for SERS substrates under laser irradiation using Kelvin probe force microscopy. This directly unveils the photocatalytic effect of Ag‐SERS substrates. Based on the presented results, it is proposed that plasmonic photocatalysis dominates sample degradation in SERS experiments and the suppression of typical SERS sample degradation by iodide is discussed by means of the energy levels of the substrate under mild irradiation conditions. This approach paves the way toward more reliable and reproducible SERS studies of biomolecules under physiological conditions.
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Research context

Catalysis & surfaces

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Biosensors and Analytical Detection · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Leibniz Institute of Photonic Technology (IPHT) Albert‐Einstein‐Str. 9 07745 Jena Germany

Institute of Physical Chemistry (IPC) and Abbe Center of Photonics Friedrich Schiller University Jena Lessingstr. 10 07743 Jena Germany

Jena Center for Soft Matter (JCSM) Friedrich Schiller University Jena Philosophenweg 7 07743 Jena Germany

Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena Humboldtstr. 10 07743 Jena Germany

Institute of Inorganic and Analytical Chemistry (IAAC) Friedrich Schiller University Jena Humboldtstr. 8 07743 Jena Germany

Department of Microbial Pathogenicity Mechanisms Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Beutenbergstrasse 11a 07745 Jena Germany

Institute of Microbiology Friedrich Schiller University Jena Neugasse 25 07743 Jena Germany

Institute For Quantum Science and Engineering (IQSE) Texas A&M University College Station TX 77843 USA

Funding

Deutsche Forschungsgemeinschaft

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