Novel Nanoencapsulation Technology and its Potential Role in Bile Acid‐Based Targeted Gene Delivery to the Inner Ear
Source abstract
Abstract
Abstract Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in particular the sensitive hair cells, can impact individuals for the rest of their lives. There are very limited options for interventions after damage to these cells has occurred. Targeted gene delivery may provide an effective means to trigger appropriate differentiation of progenitor cells for effective replacement of these sensitive hair cells. There are several hurdles that need to be overcome to effectively deliver these genes. Nanoencapsulation technology has previously been used for the delivery of pharmaceuticals, proteins and nucleic acids, and may provide an effective means of delivering genes to trigger appropriate differentiation. This review investigates the background of hearing loss, current advancements and pitfalls of gene delivery, and how nanoencapsulation may be useful.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Hearing, Cochlea, Tinnitus, Genetics · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Biotechnology and Drug Development Research Laboratory Curtin Medical School & Curtin Health Innovation Research Institute Curtin University Bentley 6102 Perth Western Australia Australia
Hearing Therapeutics Ear Science Institute Australia Queen Elizabeth II Medical Centre Nedlands 6009 Perth Western Australia Australia
School of Pharmacy University of Otago Dunedin Otago 9016 New Zealand
Medical School University of Western Australia Perth Western Australia Australia
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