DataVXSmallPaper
journal article·2014-11

Cancer Therapy: Folic Acid Functionalized Surface Highlights 5‐Methylcytosine‐Genomic Content within Circulating Tumor Cells (Small 21/2014)

Natalia Malara, Maria Laura Coluccio, Tania Limongi, Monica Asande, Valentina Trunzo, Gheorghe Cojoc, Cinzia Raso, Patrizio Candeloro, Gerardo Perozziello, Raffaella Raimondo, Stefania De Vitis, Laura Roveda, Maria Renne, Ubaldo Prati, Vincenzo Mollace, Enzo Di Fabrizio

Small· Volume 10· Issue 21
Publisher page
Source abstract

Abstract

A folic acid (FA)-functionalized surface, able to selectively entrap circulating tumor cell (CTC)-expressing folic receptors, is developed by E. Di Fabrizio and co-workers on page 4324. Since FA represents a good transducer highlighting the CTC global 5-methylcytosine content, this functionalized surface represents an important tool to profile cellular methylation changes in tumor monitoring strategies. The image shows CTCs under a scanning electron microscope after fixation and metallization. Image credit: M. Orlando, R. Ruffilli, and V. Shalabaeva.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Epigenetics and DNA Methylation · Cancer Research and Treatments · RNA modifications and cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Italian Institute of Technology Arnesano Lecce Italy

BIONEM, University of Magna Graecia Campus S. Venuta, Viale Europa 88100 Catanzaro Italy

Physical Science & Engineering Division King Abdullah University of Science and Technology Kingdom of Saudi Arabia

Faculty of Pharmacy University of Magna Graecia Campus Salvatore Venuta Viale Europa 88100 Catanzaro Italy

Max Planck Institute of Molecular, Cell Biology and Genetics Pfotenhauerstrasse 108 01307 Dresden Germany

Systems Biology Ireland Conway Institute UCD Belfield Dublin

Oncologic Surgery Cancer Centre of Excellence “Tommaso Campanella” Foundation Viale Europa 88100 Catanzaro Italy

Interregional Research Center on Food Safety & Health (IRC‐FSH) Department of Health Sciences University Magna Graecia of Catanzaro Catanzaro Italy

References

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