journal article·2016-09

Porous Matrix Stiffness Modulates Response to Targeted Therapy in Breast Carcinoma

Cuiying Liu, Xiang Li, Wenda Hua, Jianjun Li, Xinxiao Han, Qing Ha, Jiantao Feng, Fulong Liao, Dongguo Li, Dong Han

Small· Volume 12· Issue 34
Publisher page

Abstract

Porous matrix stiffness modulates response to targeted therapy. Poroelastic behavior within porous matrix may modulate the molecule events in cell-matrix and cell–cell interaction like the complex formation of human epidermal growth factor receptor-2 (HER2)-Src-α6β4 integrin, influencing the targeted therapy with lapatinib. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cell Adhesion Molecules Research · Cellular Mechanics and Interactions · HER2/EGFR in Cancer Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Center for Nanoscience and Technology Beijing 100190 P. R. China

Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 P. R. China

Institute of Biomedical Engineering Capital Medical University Beijing 100069 P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality

References (28)

Show source-provided references
1. 10.1007/s10439-011-0252-210.1007/s10439-011-0252-2 ↗
2. 10.1016/j.cell.2006.06.04410.1016/j.cell.2006.06.044 ↗
3. 10.1002/hep.2179210.1002/hep.21792 ↗
4. 10.1016/S0006-3495(00)76279-510.1016/S0006-3495(00)76279-5 ↗
5. 10.1007/s12274-014-0409-z10.1007/s12274-014-0409-z ↗
6. 10.1063/1.337035410.1063/1.3370354 ↗
7. 10.1002/hep.2410810.1002/hep.24108 ↗
8. Feng J. T. · Clin. Hemorheol. Microcirc. · 2013 · 55 · 12110.3233/CH-131696 ↗
9. 10.1016/j.biomaterials.2014.03.05810.1016/j.biomaterials.2014.03.058 ↗
10. 10.1038/nm.293810.1038/nm.2938 ↗
11. 10.1016/j.yexcr.2010.02.04510.1016/j.yexcr.2010.02.045 ↗
12. 10.1126/science.379810610.1126/science.3798106 ↗
13. 10.1016/j.ctrv.2012.04.00810.1016/j.ctrv.2012.04.008 ↗
14. 10.1039/B610522J10.1039/B610522J ↗
15. 10.1038/nmat405110.1038/nmat4051 ↗
16. 10.1038/nmat333910.1038/nmat3339 ↗
17. 10.1016/j.tips.2007.08.00410.1016/j.tips.2007.08.004 ↗
18. 10.1016/j.tcb.2006.05.00410.1016/j.tcb.2006.05.004 ↗
19. 10.1016/j.cell.2006.05.04710.1016/j.cell.2006.05.047 ↗
20. 10.1016/j.cell.2006.07.02010.1016/j.cell.2006.07.020 ↗
21. 10.1038/nmat434210.1038/nmat4342 ↗
22. 10.1038/nmat400910.1038/nmat4009 ↗
23. Yoshioka T. · J. Clin. Invest. · 2013 · 123 · 682
24. Jelovac D. · Oncology (Williston Park) · 2013 · 27 · 166
25. 10.1038/bonekey.2012.9610.1038/bonekey.2012.96 ↗
26. 10.1016/j.tips.2006.04.00110.1016/j.tips.2006.04.001 ↗
27. Tse J. R. · Curr. Protoc. Cell Biol. · 2010 · 10 · 16
28. 10.1016/j.biomaterials.2009.05.01310.1016/j.biomaterials.2009.05.013 ↗