Rapid Cell Patterning Induced by Differential Topography on Silica Nanofractal Substrates

Predesigned silica nanofractal substrates are utilized for rapid cell patterning, based on differential cell adhesion originating from surface topographic interactions. Cell patterns with various shapes are successfully formed, from simple geometrical shapes to a complex “CELL” symbol. This study assists understanding of cell–substrate interactions and facilitates biological applications. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.