Chemically Engineered Nanoparticle–Protein Interface for Real‐Time Cellular Oxidative Stress Monitoring
Source abstract
Abstract
A co-engineered nanoparticle/protein peroxide detector is created. This system features a gold nanoparticle functionalized with a galactose headgroup (AuNP-Gal) that reacts covalently with a boronate-modified green fluorescent protein (PB-GFP). Boronate acid-saccharide complexation between PB-GFP and AuNP-Gal affords a highly stable assembly. This complex is disrupted by peroxide, allowing quantitative and selective monitoring of hydrogen peroxide production in real time.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Molecular Sensors and Ion Detection · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry University of Massachusetts Amherst 710 North Pleasant Street Amherst MA 01003 USA
Department of Biomedical Engineering Tufts University 4 Colby Street Medford MA 02115 USA
Funding
National Institutes of Health · National Science Foundation
References (36)
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