DNA Aptamer‐Passivated Nanocrystal Synthesis: A Facile Approach for Nanoparticle‐Based Cancer Cell Growth Inhibition

A class of DNA aptamers, recognizing and therapeutically targeting cancer cells, remains functional while forming stable colloidal PbS and Fe3O4 nanocrystals. The aptamer-passivated nanocrystals (see image) are non-cytotoxic to normal cells, whereas MCF-7 human breast cancer cells incorporated with these particles have significantly reduced proliferation. The nanoparticle-aptamer systems provide a platform for novel nanoparticle therapeutics. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.