Stabilization of Vaterite in Nanostructured CaCO3 via Precipitation: Implications for Drug Delivery Systems
Source abstract
Abstract
Polycrystalline vaterite aggregates of approximately 2000 nm composed of 50–100 nm nanoparticles were grown by precipitation routes. Different aggregate morphologies─including raspberry-shaped, star-like, spindle, lenticular, and spherical forms─were stabilized by adjusting synthesis parameters such as pH, temperature, order of the limiting and excess reactants, and the use of simple organic additives such as polyethylene glycol (PEG) and gelatin. Vaterite with a raspberry-shaped morphology and > 99% purity was obtained by adding CaCl 2 dropwise to a PEG-Na 2 CO 3 solution using an infusion pump at 50 mL/h, under continuous stirring at pH 10 and 35 °C. The resulting batch was homogeneous and remained stable at normal laboratory conditions for at least 3 years, becoming an interesting material for drug delivery in human cancer therapies. Finally, a systematic correlation between aggregate morphology, crystallite size, and the stability of the vaterite phase was established, highlighting the role of nanostructuring in preventing its transformation into more stable CaCO 3 polymorphs.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Calcium Carbonate Crystallization and Inhibition · Bone Tissue Engineering Materials · Clay minerals and soil interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Departamento de Desarrollo de Radioisótopos y Radiofármacos, Centro Integral de Medicina Nuclear y Radioterapia de Bariloche, Comisión Nacional de Energía Atómica (CNEA), Ruta 82 s/n, San Carlos de Bariloche, Río Negro 8400, Argentina
Universidad Nacional de San Martín (UNSAM), Av, 25 de mayo 1169, San Martín, Buenos Aires 1650, Argentina
Laboratorio de Cristalografía Aplicada, Instituto de Tecnologías Emergentes y Ciencias Aplicadas (ITECA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) − Universidad Nacional de San Martín (UNSAM). Av 25 de mayo 1169, San Martín, Buenos Aires 1650, Argentina
Instituto de Nanociencia y Nanotecnología (INN), Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA) − Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Bustillo 9500, San Carlos de Bariloche, Río Negro 8400, Argentina
Funding
Consejo Nacional de Investigaciones Cient?ficas y T?cnicas · Agencia Nacional de Promoci?n de la Investigaci?n, el Desarrollo Tecnol?gico y la Innovaci?n
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