Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment‐Controlled Multistage Drug‐Release in Neurons
Source abstract
Abstract
Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain‐disease therapy, a drug delivery system that can sustainably control drug‐release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light‐traceable and intracellular microenvironment‐responsive drug delivery system was developed based on the combination of glutathione‐responsive autoflurescent nanogel, dendrimer‐like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage‐release of sulfydryl‐containing drugs into neurons, with light‐traceable monitoring for future brain‐disease therapy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Dendrimers and Hyperbranched Polymers · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Life Sciences Henan University Jin Ming Avenue Kaifeng Henan 475004 China
Department of Chemistry & Biological Engineering University of Science & Technology Beijing Beijing 100083 P. R. China
Faculty of Medicine & Health Sciences Macquarie University Sydney NSW 2109 Australia
Institute of Advanced Materials for Nano‐Bio Applications Wenzhou Medical University Wenzhou Zhejiang 325027 China
Funding
National Natural Science Foundation of China · National Health and Medical Research Council
References (64)
Show source-provided references
1. 10.1517/13543784.6.2.16910.1517/13543784.6.2.169 ↗
2. 10.1016/S0009-9120(03)00059-610.1016/S0009-9120(03)00059-6 ↗
3. 10.3109/1071576920904916410.3109/10715769209049164 ↗
4. 10.1016/S0140-6736(77)92958-010.1016/S0140-6736(77)92958-0 ↗
5. 10.1016/0378-5173(82)90083-710.1016/0378-5173(82)90083-7 ↗
6. 10.1016/0002-9343(86)90722-910.1016/0002-9343(86)90722-9 ↗
7. 10.1002/smll.20160172410.1002/smll.201601724 ↗
8. 10.1021/bm201380e10.1021/bm201380e ↗
9. 10.1002/adma.20130218910.1002/adma.201302189 ↗
10. 10.1002/smll.20130243010.1002/smll.201302430 ↗
11. 10.1002/adma.20070172610.1002/adma.200701726 ↗
12. 10.1002/adma.20130218910.1002/adma.201302189 ↗
13. 10.1021/nn901403210.1021/nn9014032 ↗
14. 10.1021/nn103213y10.1021/nn103213y ↗
15. 10.1016/j.addr.2011.12.00610.1016/j.addr.2011.12.006 ↗
16. 10.1038/nrd.2015.2110.1038/nrd.2015.21 ↗
17. 10.1002/elsc.20140004310.1002/elsc.201400043 ↗
18. 10.1002/smll.20160222510.1002/smll.201602225 ↗
19. 10.1002/smll.20100140210.1002/smll.201001402 ↗
20. 10.1002/smll.20090178910.1002/smll.200901789 ↗
21. 10.1002/anie.20060448810.1002/anie.200604488 ↗
22. 10.1002/jps.2230810.1002/jps.22308 ↗
23. 10.1002/cphc.20050029410.1002/cphc.200500294 ↗
24. 10.1002/adma.20130218910.1002/adma.201302189 ↗
25. 10.1021/ar200018x10.1021/ar200018x ↗
26. 10.1038/nnano.2008.3410.1038/nnano.2008.34 ↗
27. 10.1039/C5CS00243E10.1039/C5CS00243E ↗
28. 10.1002/adfm.20130366210.1002/adfm.201303662 ↗
29. 10.1002/anie.20100082710.1002/anie.201000827 ↗
30. 10.1021/ja103415t10.1021/ja103415t ↗
31. 10.1002/smll.20160112910.1002/smll.201601129 ↗
32. 10.1021/ja907838s10.1021/ja907838s ↗
33. 10.1016/j.biomaterials.2010.11.02010.1016/j.biomaterials.2010.11.020 ↗
34. 10.1002/anie.20100413310.1002/anie.201004133 ↗
35. 10.1021/ja806088610.1021/ja8060886 ↗
36. 10.1021/ja028650l10.1021/ja028650l ↗
37. 10.1021/ja057254a10.1021/ja057254a ↗
38. 10.1021/nn901181c10.1021/nn901181c ↗
39. 10.1021/ja801631c10.1021/ja801631c ↗
40. 10.1021/ja00200a03910.1021/ja00200a039 ↗
41. 10.1016/S0009-8981(98)00089-810.1016/S0009-8981(98)00089-8 ↗
42. 10.1038/nmat216210.1038/nmat2162 ↗
43. 10.1039/c3cc38761e10.1039/c3cc38761e ↗
44. 10.1021/acs.nanolett.6b0351710.1021/acs.nanolett.6b03517 ↗
45. 10.1021/acs.chemrev.5b0034610.1021/acs.chemrev.5b00346 ↗
46. 10.1073/pnas.96.9.517710.1073/pnas.96.9.5177 ↗
47. 10.1021/nn900918w10.1021/nn900918w ↗
48. 10.1021/ja200555z10.1021/ja200555z ↗
49. 10.1038/nature0238810.1038/nature02388 ↗
50. 10.1038/nrd177510.1038/nrd1775 ↗
51. 10.1002/adhm.20140018710.1002/adhm.201400187 ↗
52. 10.1002/adhm.20160023010.1002/adhm.201600230 ↗
53. 10.1002/anie.20140929310.1002/anie.201409293 ↗
54. 10.1021/la034209c10.1021/la034209c ↗
55. 10.1016/j.micromeso.2005.12.00410.1016/j.micromeso.2005.12.004 ↗
56. 10.1021/jp102368s10.1021/jp102368s ↗
57. Beganskiene· A. · Mater. Sci. · 2004 · 10 · 287
58. 10.1016/0926-2040(93)90005-810.1016/0926-2040(93)90005-8 ↗
59. 10.1021/cm060598v10.1021/cm060598v ↗
60. 10.1016/S0891-5849(01)00480-410.1016/S0891-5849(01)00480-4 ↗
61. 10.1039/c3cc38761e10.1039/c3cc38761e ↗
62. 10.4314/tjpr.v7i3.1469210.4314/tjpr.v7i3.14692 ↗
63. 10.1016/j.jconrel.2011.01.03010.1016/j.jconrel.2011.01.030 ↗
64. 10.1016/S0891-5849(01)00480-410.1016/S0891-5849(01)00480-4 ↗