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journal article·2017-08Open access

Dual‐Action Cancer Therapy with Targeted Porous Silicon Nanovectors

Anna Cifuentes‐Rius, Angela Ivask, Ester Sporleder, Ishdeep Kaur, Yasmin Assan, Shasha Rao, David Warther, Clive A. Prestidge, Jean‐Olivier Durand, Nicolas H. Voelcker

Small· Volume 13· Issue 29
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Source abstract

Abstract

There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody‐functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two‐stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.
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Research context

Nanomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology Future Industries Institute University of South Australia Mawson Lakes SA 5095 Australia

School of Pharmacy and Medical Sciences University of South Australia City East Campus Adelaide SA 5000 Australia

Institut Charles Gerhardt Montpellier UMR‐5253 CNRS‐UM‐ENSCM‐UM1cc, 1701 Place Eugène Bataillon F‐34095 Montpelliercedex 05 France

Funding

National Health and Medical Research Council · Australian Research Council · Deutscher Akademischer Austauschdienst · European Regional Development Fund

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