Multidimensional Oriented Piezoelectric Conduits for Peripheral Nerve Defect Regeneration
Source abstract
Abstract
ABSTRACT Peripheral nerve regeneration and functional recovery hold immense clinical significance, as they are critical for reinnervating the motor and sensory functions of organs. In this study, piezoelectric nerve guidance conduits (NGCs) with multidimensional oriented structures and zinc oxide (ZnO) nanoparticles were developed for this purpose, fabricated via a combination of digital light processing (DLP) 3D printing and directional freezing technologies. The therapeutic efficacy of the NGCs was evaluated in a rat model of sciatic nerve defect, with continuous monitoring of neuromorphological and functional recovery metrics. Results indicated that the oriented structure of the NGCs and the piezoelectrically generated electric field significantly promoted both morphological regeneration and functional restoration of peripheral nerves, achieving repair effects comparable to the gold‐standard autologous nerve transplantation. This work presents a promising strategy for the clinical treatment of peripheral nerve defects.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nerve injury and regeneration · Neuroscience and Neural Engineering · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Rehabilitation Medicine and Institute of Rehabilitation Medicine West China Hospital Sichuan University Chengdu Sichuan China
Key Laboratory of Rehabilitation Medicine in Sichuan Province Chengdu Sichuan China
College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials Sichuan University Chengdu China
National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University Chengdu China
Department of Neurosurgery The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan Shandong China
Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital Department of Neurosurgery Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China
Sports medicine center Southwest hospital Third military medical university (Army medical university) Chongqing China
Funding
National Natural Science Foundation of China
References (69)
Show source-provided references
1. 10.1021/acsbiomaterials.6b0050010.1021/acsbiomaterials.6b00500 ↗
2. 10.1038/s41591‐018‐0196‐210.1038/s41591‐018‐0196‐2 ↗
3. 10.1126/scitranslmed.aav775310.1126/scitranslmed.aav7753 ↗
4. 10.1016/j.cej.2022.13942410.1016/j.cej.2022.139424 ↗
5. 10.1089/ten.tea.2009.001710.1089/ten.tea.2009.0017 ↗
6. 10.1007/s10544‐007‐9068‐010.1007/s10544‐007‐9068‐0 ↗
7. 10.1002/adfm.20200261010.1002/adfm.202002610 ↗
8. 10.1002/jbm.a.3571410.1002/jbm.a.35714 ↗
9. 10.1007/s10439‐006‐9126‐410.1007/s10439‐006‐9126‐4 ↗
10. 10.1021/acsabm.0c0113910.1021/acsabm.0c01139 ↗
11. 10.1038/s41427‐019‐0110‐510.1038/s41427‐019‐0110‐5 ↗
12. 10.1016/j.cej.2023.14793310.1016/j.cej.2023.147933 ↗
13. 10.1016/j.nantod.2023.10181410.1016/j.nantod.2023.101814 ↗
14. 10.1016/j.bioactmat.2020.09.03010.1016/j.bioactmat.2020.09.030 ↗
15. 10.1002/adfm.20190669010.1002/adfm.201906690 ↗
16. 10.1016/j.bioactmat.2020.08.01010.1016/j.bioactmat.2020.08.010 ↗
17. 10.1039/d0tb00779j10.1039/d0tb00779j ↗
18. 10.1016/j.ijpharm.2023.12328310.1016/j.ijpharm.2023.123283 ↗
19. 10.1089/ten.tea.2014.026610.1089/ten.tea.2014.0266 ↗
20. 10.1016/j.mehy.2008.05.01010.1016/j.mehy.2008.05.010 ↗
21. 10.1016/j.cej.2025.16212410.1016/j.cej.2025.162124 ↗
22. 10.1016/j.biomaterials.2010.03.08110.1016/j.biomaterials.2010.03.081 ↗
23. 10.1016/j.biomaterials.2014.11.03510.1016/j.biomaterials.2014.11.035 ↗
24. 10.1016/j.bioactmat.2024.07.01810.1016/j.bioactmat.2024.07.018 ↗
25. 10.1002/advs.20210387510.1002/advs.202103875 ↗
26. 10.1186/s12951‐024‐02475‐810.1186/s12951‐024‐02475‐8 ↗
27. 10.1016/j.actbio.2017.07.03110.1016/j.actbio.2017.07.031 ↗
28. 10.1016/j.biomaterials.2006.07.04310.1016/j.biomaterials.2006.07.043 ↗
29. 10.1002/anie.20181447410.1002/anie.201814474 ↗
30. 10.1016/j.mtadv.2023.10034310.1016/j.mtadv.2023.100343 ↗
31. 10.1016/j.bioactmat.2021.06.02710.1016/j.bioactmat.2021.06.027 ↗
32. 10.1002/adhm.20220096510.1002/adhm.202200965 ↗
33. 10.3390/pharmaceutics1512276010.3390/pharmaceutics15122760 ↗
34. 10.1016/j.biomaterials.2020.12016410.1016/j.biomaterials.2020.120164 ↗
35. 10.3389/fbioe.2019.0026610.3389/fbioe.2019.00266 ↗
36. 10.3390/biomedicines1112319510.3390/biomedicines11123195 ↗
37. 10.22541/au.171468403.30844874/v110.22541/au.171468403.30844874/v1 ↗
38. 10.1016/j.ijbiomac.2024.13239410.1016/j.ijbiomac.2024.132394 ↗
39. 10.1016/j.nanoen.2019.10441110.1016/j.nanoen.2019.104411 ↗
40. 10.1007/s42235‐024‐00526‐210.1007/s42235‐024‐00526‐2 ↗
41. 10.1016/j.nantod.2024.10222810.1016/j.nantod.2024.102228 ↗
42. 10.1016/j.nanoen.2024.11054210.1016/j.nanoen.2024.110542 ↗
43. 10.1152/physrev.00020.200410.1152/physrev.00020.2004 ↗
44. 10.1016/j.ceramint.2024.03.17810.1016/j.ceramint.2024.03.178 ↗
45. 10.1016/j.clay.2023.10702410.1016/j.clay.2023.107024 ↗
46. 10.1016/j.jmst.2025.02.04610.1016/j.jmst.2025.02.046 ↗
47. 10.1021/acs.chemmater.1c0394410.1021/acs.chemmater.1c03944 ↗
48. 10.1007/s42765‐023‐00281‐910.1007/s42765‐023‐00281‐9 ↗
49. 10.3390/molecules2405090910.3390/molecules24050909 ↗
50. 10.1002/jbm.a.37503Digital10.1002/jbm.a.37503Digital ↗
51. 10.1016/j.biotechadv.2013.09.00710.1016/j.biotechadv.2013.09.007 ↗
52. 10.1007/s42765‐024‐00447‐z10.1007/s42765‐024‐00447‐z ↗
53. 10.3390/biomedicines904035210.3390/biomedicines9040352 ↗
54. 10.1016/j.mtcomm.2024.10825110.1016/j.mtcomm.2024.108251 ↗
55. 10.1002/adhm.20230149410.1002/adhm.202301494 ↗
56. 10.1021/acschemneuro.9b0020310.1021/acschemneuro.9b00203 ↗
57. 10.1177/154596831560439910.1177/1545968315604399 ↗
58. 10.1002/adhm.20220319910.1002/adhm.202203199 ↗
59. 10.1002/smll.20250293910.1002/smll.202502939 ↗
60. 10.1126/sciadv.ado912010.1126/sciadv.ado9120 ↗
61. 10.1016/j.bioactmat.2024.05.03310.1016/j.bioactmat.2024.05.033 ↗
62. 10.13201/j.issn.2096‐7993.2024.05.01210.13201/j.issn.2096‐7993.2024.05.012 ↗
63. 10.1063/5.018918110.1063/5.0189181 ↗
64. 10.1007/s12031‐024‐02286‐410.1007/s12031‐024‐02286‐4 ↗
65. 10.1016/j.colsurfb.2023.11367210.1016/j.colsurfb.2023.113672 ↗
66. 10.7314/apjcp.2013.14.11.621510.7314/apjcp.2013.14.11.6215 ↗
67. 10.1007/s10974‐012‐9328‐310.1007/s10974‐012‐9328‐3 ↗
68. 10.1016/j.compositesb.2022.11016310.1016/j.compositesb.2022.110163 ↗
69. 10.1038/s41586‐021‐03212‐z10.1038/s41586‐021‐03212‐z ↗