Herb‐Metal Ion Coordination Compounds with Photo/Electromagnetic Wave Response for Developing Various Anti‐Infection Strategies
Source abstract
Abstract
Abstract The global rise in infectious diseases and antibiotic overuse exacerbate bacterial drug resistance, particularly in multidrug‐resistant pathogens like methicillin‐resistant Staphylococcus aureus (MRSA). While plant‐derived flavones exhibit multi‐target antibacterial mechanisms that overcome resistance, their therapeutic application remains constrained by poor aqueous dispersibility and stability. Herein, a luteolin‐iron complex (Lut‐Fe3⁺) is engineered through a facile coordination approach, where Fe3⁺ facilitates d‐orbital splitting and generation of high‐spin electrons. This octahedral complex demonstrates exceptional water dispersibility and exhibits broad‐spectrum absorption across ultraviolet to microwave (MW) frequencies. Lut‐Fe3⁺ demonstrates dual antimicrobial modalities: long‐term antisepsis in the dark and rapid sterilization under light/MW irradiation. This multi‐functional complex is further combined with various methods to develop therapeutic strategies for bacterial infections at different depths. Notably, the Lut‐Fe3⁺ is engineered into an MW‐responsive nebulization system, achieving effective eradication of MRSA‐induced deep‐tissue pneumonia in mice.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Sulfur Compounds in Biology · Molecular Sensors and Ion Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science & Engineering The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University Yaguan Road 135# Tianjin 300072 China
Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry‐of‐Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Youyi Avenue 368# Wuhan 430062 China
School of Health Science & Biomedical Engineering Hebei University of Technology Xiping Avenue 5340# Tianjin 300401 China
School of Materials Science & Engineering Peking University Yi‐He‐Yuan Road 5# Beijing 100871 China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality · State Key Laboratory of Advanced Technology for Materials Synthesis and Processing · China National Funds for Distinguished Young Scientists
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