From Science to Solutions: Translating DNA‐Based Nanodevices into Clinical Applications
Source abstract
Abstract
Abstract DNA nanotechnology has emerged as a transformative platform in molecular medicine over the past four decades. The structural and functional versatility of nanostructures like DNA origami, hydrogels, and aptamer‐based systems, as well as their programmable, biocompatible natures, have contributed toward significant advances in a biomedical context, such as cancer‐targeted therapies, infectious disease detection, gene delivery, novel tissue engineering, and regenerative medicine. Despite promising preclinical experiment data, actual clinical translation remains limited in the face of key challenges–biostability, immunogenicity, scalable manufacturing, and regulatory hurdles. This review provides a comprehensive overview of the field's pathway from fundamental principles to viable, real‐world, clinical solutions. These barriers are critically evaluated, with a focus on optimizing safety, delivery, and in‐vivo performance, and discuss emerging strategies to overcome these limitations, including DNA–protein hybrids, protective coatings, responsive designs, harnessing AI capacity and automation‐enabled production pipelines, by combining insights from basic science, engineering, and translational medicine.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Nanowire Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biology Indian Institute of Science Education and Research (IISER) Pune Maharashtra 411008 India
Department of Biotechnology National Institute of Technology (NIT) Warangal Telangana 506004 India
Department of Biological Sciences and Engineering Indian Institute of Technology Gandhinagar Palaj Gujarat 382355 India
Funding
Department of Biotechnology, Ministry of Science and Technology, India
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