Bio‐Responsive Macromolecular Drug and Small‐Molecular Drug Conjugates: Nanoparticulate Prodrugs for Tumor Microenvironment Heterogeneity Management and Therapeutic Response Enhancement (Small 39/2023)

Nanoparticulate Prodrugs In article number 2301656, Xianghui Xu and co-workers present nanoparticulate prodrugs based on bio-responsive macromolecular drug and small-molecular drug conjugates for tumor microenvironment heterogeneity management and therapeutic response enhancement. This nanomedicine strategy achieves site-specific delivery of macromolecular and small-molecular drugs within tumor tissues, providing efficient management on tumor extracellular matrix, interstitial pressure, vascular network, blood flow, and hypoxia.