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journal article·2024-11

A Janus Microsphere Delivery System Orchestrates Immunomodulation and Osteoinduction by Fine‐tuning Release Profiles

Yang Shi, Jingyi Gu, Chun Zhang, Rui Mi, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Changyu Shao, Yong He, Jue Shi, Zhijian Xie

Small· Volume 20· Issue 46
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Source abstract

Abstract

Abstract Bone regeneration is a well‐orchestrated process synergistically involving inflammation, angiogenesis, and osteogenesis. Therefore, an effective bone graft should be designed to target multiple molecular events and biological demands during the bone healing process. In this study, a biodegradable gelatin methacryloyl (GelMA)‐based Janus microsphere delivery system containing calcium phosphate oligomer (CPO) and bone morphogenetic protein‐2 (BMP‐2) is developed based on natural biological events. The exceptional adjustability of GelMA facilitates the controlled release and on‐demand application of biomolecules, and optimized delivery profiles of CPO and BMP‐2 are explored. The sustained release of CPO during the initial healing stages contributes to early immunomodulation and promotes mineralization in the late stage. Meanwhile, the administration of BMP‐2 at a relatively high concentration within the therapeutic range enhances the osteoinductive property. This delivery system, with fine‐tuned release patterns, induces M2 macrophage polarization and creates a conducive immuno‐microenvironment, which in turn facilitates effective bone regeneration in vivo. Collectively, this study proposes a bottom‐up concept, aiming to develop a user‐friendly and easily controlled delivery system targeting individual biological events, which may offer a new perspective on developing function‐optimized biomaterials for clinical use.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou 310000 China

Plastic and Reconstructive Surgery Center Department of Plastic and Reconstructive Surgery Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College Hangzhou 310014 China

State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang University Hangzhou 310027 China

Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical Engineering Zhejiang University Hangzhou 310027 China

Liangzhu Laboratory Zhejiang University 1369 West Wenyi Road Hangzhou 311121 China

The Second Affiliated Hospital of Zhejiang University and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China

Funding

National Natural Science Foundation of China · Postdoctoral Research Foundation of China · Key Research and Development Program of Zhejiang Province

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