Lipidated DNA Nanostructures Target and Rupture Bacterial Membranes
Source abstract
Abstract
Abstract Chemistry has the power to endow supramolecular nanostructures with new biomedically relevant functions. Here it is reported that DNA nanostructures modified with cholesterol tags disrupt bacterial membranes to cause microbial cell death. The lipidated DNA nanostructures bind more readily to cholesterol‐free bacterial membranes than to cholesterol‐rich, eukaryotic membranes. These highly negatively charged, lipidated DNA nanostructures cause bacterial cell death by rupturing membranes. Strikingly, killing is mediated by clusters of barrel‐shaped nanostructures that adhere to the membrane without the involvement of expected bilayer‐puncturing barrels. These DNA nanomaterials may inspire the development of polymeric or small‐molecule antibacterial agents that mimic the principles of selective binding and rupturing to help combat antimicrobial resistance.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Antimicrobial Peptides and Activities · Bacteriophages and microbial interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
London Centre for Nanotechnology University College London 17–19 Gordon Street London WC1H 0AH United Kingdom
Division of Medicine University College London, Cruciform Building Gower Street London WC1E 6BT United Kingdom
Department of Chemistry, Institute of Structural Molecular Biology University College London London WC1H 0AJ United Kingdom
National Physical Laboratory Teddington TW11 0LW United Kingdom
Department of Physics King’s College London Strand Lane London WC2R 2LS United Kingdom
Department of Materials Science and Engineering University of Sheffield Sir Robert Hadfield Building Sheffield S1 3JD United Kingdom
Funding
Engineering and Physical Sciences Research Council · Medical Research Council · UK Research and Innovation · Biotechnology and Biological Sciences Research Council
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