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journal article·2024-04

Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment

Min Ji Byun, Hee Seung Seo, Joonghak Lee, Kitae Ban, Serim Oh, Yun Young Lee, Jaesung Lim, Na Kyeong Lee, Chi‐Pin James Wang, Minjeong Kim, Jun‐Hyeok Han, Juwon Park, Taejong Paik, Hee Ho Park, Tae‐Eun Park, Wooram Park, Se‐Na Kim, Dae‐Hwan Park, Chun Gwon Park

Small· Volume 20· Issue 17
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Source abstract

Abstract

Abstract Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole‐3‐acetic acid‐loaded layered double hydroxides (IAA‐LDHs) is evaluated as a novel treatment for AD. IAA is an auxin‐class plant hormone with antioxidant and anti‐inflammatory effects. Following the synthesis of IAA‐LDH nanohybrids, their ability to induce M2‐like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA‐LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti‐inflammatory and anti‐atopic characteristics of IAA‐LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA‐LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Dermatology and Skin Diseases · Eosinophilic Esophagitis · Endometriosis Research and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering SKKU Institute for Convergence Sungkyunkwan University (SKKU) Suwon Gyeonggi 16419 Republic of Korea

Department of Intelligent Precision Healthcare Convergence SKKU Institute for Convergence Sungkyunkwan University (SKKU) Suwon Gyeonggi 16419 Republic of Korea

Department of Engineering Chemistry Chungbuk National University Cheongju Chungbuk 28644 Republic of Korea

Department of Biomedical Engineering Seoul National University College of Medicine Seoul 03080 Republic of Korea

Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University (SKKU) Suwon Gyeonggi 16419 Republic of Korea

Department of Tropical Medicine Medical Microbiology and Pharmacology John A. Burns School Medicine University of Hawai'i at Manoa Honolulu Hawaii 96813 USA

School of Integrative Engineering Chung‐Ang University Seoul 06974 Republic of Korea

Department of Bioengineering Hanyang University Seoul 04763 Republic of Korea

Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea

Biomaterials Research Center Korea Institute of Science and Technology Seoul 02792 Republic of Korea

Research and Development Center MediArk Inc. Cheongju Chungbuk 28644 Republic of Korea

Department of Industrial Cosmetic Science College of Bio‐Health University System Chungbuk National University Cheongju Chungbuk 28644 Republic of Korea

Department of Synchrotron Radiation Science and Technology College of Bio‐Health University System Chungbuk National University Cheongju Chungbuk 28644 Republic of Korea

LANG SCIENCE Inc Cheongju Chungbuk 28644 Republic of Korea

Biomedical Institute for Convergence at SKKU (BICS) Sungkyunkwan University (SKKU) Suwon Gyeonggi 16419 Republic of Korea

Funding

Ministry of Education

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