Oxygen‐Bonded Amorphous Transition Metal Dichalcogenides with pH‐Responsive Reactive Oxygen Biocatalysis for Combined Antibacterial and Anti‐inflammatory Therapies in Diabetic Wound Healing

Abstract Diabetic wound healing is a formidable challenge, often complicated by biofilms, immune dysregulation, and hindered vascularization within the wound environments. The intricate interplay of these microenvironmental factors has been a significant oversight in the evolution of therapeutic strategies. Herein, the design of an efficient and versatile oxygen‐bonded amorphous transition metal dichalcogenide biocatalyst (aRuS‐O _r ) with pH‐responsive reactive oxygen biocatalysis for combined antibacterial and anti‐inflammatory therapies in promoting diabetic wound healing is reported. Leveraging the incorporation of Ru─O bonds, aRuS‐O _r exhibits optimized adsorption/desorption behavior of oxygen intermediates, thereby enhancing both the reactive oxygen species (ROS) generation activity in acidic conditions and ROS scavenging performance in neutral environments. Remarkably, aRuS‐O _r demonstrates exceptional bactericidal potency within infected milieus through biocatalytic ROS generation. Beyond its antimicrobial capability, post‐eradication, aRuS‐O _r serves a dual role in mitigating oxidative stress in inflammatory wounds, providing robust cellular protection and fostering an M2‐phenotype polarization of macrophages, which is pivotal for accelerating the wound repair process. The findings underscore the multifaceted efficacy of aRuS‐O _r , which harmoniously integrates high antibacterial action with anti‐inflammatory and pro‐angiogenic properties. This triad of functionalities positions aRuS‐O _r as a promising candidate for the comprehensive management of complex diabetic ulcers, addressing the unmet needs in the current therapeutics.